Urachal mucinous neoplasms--to be or not to be: Two cases and a review of current diagnostic criteria (WHO 2016)

Juan Daniel Prieto Cuadra, Lidia Pérez, Isabel García, Martina Álvarez, Bernardo Herrera, Isabel Hierro, Luis Vicioso


The urachus is an embryological remnant that extends from the bladder to the umbilicus. Urachal neoplasms represent less than 1% of malignant bladder tumors. The new 2016 edition of disease classifications from the WHO has updated the classification of epithelial neoplasms of urachal origin, distinguishing between glandular and non-glandular neoplasms and between cystic and non-cystic adenocarcinomas. In this article, we present two cases with similar clinical presentations but differing histology. We address their morphological, immunohistochemical, and molecular characterization; review the classification and diagnostic criteria of glandular urachal neoplasms included in the most recent literature with the aim of clarifying their differential diagnosis as well as their prognostic implication; and, ultimately, better understand these infrequent biological entities.

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DOI: https://doi.org/10.5430/crcp.v5n1p12


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Case Reports in Clinical Pathology

ISSN 2331-2726(Print)  ISSN 2331-2734(Online)

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