Reader Comments

Intracellular calcium chelation and apoptosis

by Mr Abraham A Embi (2013-04-30)


Recently, the author finds in the medical literature a publication entitled "Calcium chelators induce apoptosis-evidence that raised intracellular ionised calcium is not essential for apoptosis (1).This evidence supports or perhaps demonstrate  the hypothesis quoted in our statement in section 3.2 (Cell death and intracellular calcium levels) of the manuscript where we state that: "Recently, the opposite, or a decrease of the available ionic calcium stores by calcium chelators (oxalates) was hypothesized to cause metastatic cancer cell death".

Sincerely,

Abraham A. Embi - Author

(1) Kluck R.M. et al. Calcium chelators induce apoptosis-evidence that raised intracellular ionised calcium is not essential for apoptosis. 1994 Biochimica et Biophysica Acta 1223 PP:247-254