Donepezil overdose - trending levels and symptoms

Allan R. Mottram, Elise ter Haar


Donepezil (Aricept) is a reversible acetylcholinesterase inhibitor used in the treatment of dementia and cognitive impairment. Side effects of the drug include nausea, vomiting, diarrhea, muscle cramps, dizziness, fatigue and anorexia. Cholinergic symptoms may occur with overdose and may be severe. We report a case of donepezil toxicity with significant bradycardia during which serial donepezil levels were measured, and are correlated with the patients’ symptoms.


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Case Reports in Internal Medicine

ISSN 2332-7243(Print)  ISSN 2332-7251(Online)

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