A unique case of pronounced neurologic deficit from paraneoplastic syndrome that precedes appearance of mediastinal germinoma by two years

Anish Nanavati, Jay Zeck, George Philips, Najeebah A. Bade


Paraneoplastic neurologic disorder may be the initial manifestation of a tumor, with the diagnosis of malignancy commonlyfound within six months of the onset of neurologic symptoms. This diagnosis is usually made on clinical grounds, as antineuronalantibodies are infrequently positive, though anti-Hu antibodies have been associated commonly with lung cancer. Typically,neurologic manifestations of germinomas include limbic and brainstem encephalitis in association with anti-Ma2 antibodies.To our knowledge, germinomas have not been associated with paraneoplastic cerebellar degeneration with anti-Hu antibodypositivity. Here we report a case where neurologic deficits and anti-Hu positivity indicative of a paraneoplastic syndrome precedesthe development of a mediastinal germinoma by two years.

Full Text:


DOI: https://doi.org/10.5430/crcp.v3n1p6


  • There are currently no refbacks.

Case Reports in Clinical Pathology

ISSN 2331-2726(Print)  ISSN 2331-2734(Online)

Copyright © Sciedu Press

To make sure that you can receive messages from us, please add the ‘sciedupress.com’ domains to your e-mail 'safe list'. If you do not receive e-mail in your 'inbox', please check your 'spam' or 'junk' folder.