Russell body cervicitis: a case report

Abstract

Russell body cervicitis was reported only twice in the literature. Herein, we reported the third case. A 35 years old female patient presented with contact bleeding. On clinical examination, the cervix showed a small polyp measuring 1 cm × 0.5 cm × 0.5 cm which was subsequently biopsied. Microscopic examination revealed papillary configuration of the surface epithelium with intense infiltration of the underlying stroma by plasma cells with eccentric nuclei and prominent eosinophilic intra-cytoplasmic globules (Russell bodies). The globules were PAS positive and the cells showed positive immunoreactivity for CD138. Increased awareness of the existence of this type of inflammation may result in future reporting of similar cases, which may help to clarify the pathogenesis and causative agent of this uncommon condition in the cervix.Russell body cervicitis was reported only twice in the literature. Herein, we reported the third case. A 35 years old female patient presented with contact bleeding. On clinical examination, the cervix showed a small polyp measuring 1 cm × 0.5 cm × 0.5 cm which was subsequently biopsied. Microscopic examination revealed papillary configuration of the surface epithelium with intense infiltration of the underlying stroma by plasma cells with eccentric nuclei and prominent eosinophilic intra-cytoplasmic globules (Russell bodies). The globules were PAS positive and the cells showed positive immunoreactivity for CD138. Increased awareness of the existence of this type of inflammation may result in future reporting of similar cases, which may help to clarify the pathogenesis and causative agent of this uncommon condition in the cervix.